Norepinephrine (noradrenaline) is both a hormone and a neurotransmitter involved in the body’s fight-or-flight response. In the brain, it influences attention, alertness, mood regulation, and stress responses.
Key Points:
- Role in Mental Health: Imbalances can contribute to mood disorders, anxiety, and PTSD. Many antidepressants (SNRIs, some tricyclics) modulate norepinephrine levels.
- Physiological Effects: Increases heart rate, blood pressure, and blood sugar levels, preparing the body for action under stress.
- Interaction with Other Neurotransmitters: Works alongside serotonin, dopamine, and others in regulating cognition, motivation, and arousal.
- Therapeutic Target: Medications influencing norepinephrine are used to treat depression, ADHD, and sometimes chronic pain or fibromyalgia.
